The Lakers had an undefeated 2006 season, winning the GLIAC title, and the NCAA Div II National Championship, ranked #1 throughout the season and finishing with a (15-0) record. In the national title match, the Lakers again faced undefeated and second-ranked Division II rivals, Northwest Missouri State University, which finished the season with a (14-1) record. The 2006 Lakers team currently holds the all-division NCAA football record for their currently-active 28-game winning streak, since the 2004 regional final. Senior quarterback Cullen Finnerty became the winningest quarterback in NCAA All-Division history, with a career record of 51-4, and was named to the 2006 American Football Coaches Association All America Team. He finished the 2006 season with a 15-0 record, completing 195 of 343 passes for 3,220 yards and 41 touchdowns, and leading the nation in quarterback efficiency with 169.32. He also rushed for 580 yards and 8 touchdowns himself, for a total offense of 3800 yards and 49 touchdowns on the season. Finnerty was awarded second place for the Harlon Hill Trophy Award, just prior to the national championship match in Florence, Alabama. During that game, held Saturday, December 16, 2006, Finnerty ran the ball more than 105 yards, leading the Lakers through an exciting game to a 17-14 victory. Finnerty, WR Eric Fowler, OL Brandon Barnes, DL Mike McFadden, LB Anthony Adams, and CB Brandon Carr each earned Daktronics First Team All American honors. Additionally, senior defensive end Michael McFadden tied the NCAA All-Division record for consecutive games with a quarterback sack (17), and broke the Division II quarterback sack record (33.5) for a career. The 2006 senior class produced a career record of 52-4 over 4 seasons. Coach Chuck Martin improved his 3-season record as the head coach to 38-3 (0.927 winning percentage), and to 86-9 overall (.905) since joining the GVSU coaching staff as an assistant in 2000.
Lakers beat the Bearcats 17-14.